When Is The Best Time To Take Multivitamins

When is the best time to take multivitamins — morning kitchen with water, berries and toast

We all want to stay healthy, and that's for sure. Harsh reality? It is hard to get everything we need from food alone. Despite consciously trying to eat and live healthily, we often fall short on several essential vitamins and minerals for optimal functioning.

Multivitamins and food supplements are a great way to fill in nutritional gaps in your diet.* They can help us get more of the vitamins and minerals our body needs for optimal health.* They're designed to supplement your diet with key nutrients that you might be missing out on.*

There are several factors we consider in choosing the best multivitamin. Many people go crazy reading through each label, checking for reviews, and asking for recommendations from friends and family members. And yet, there's one significant factor that most of us often overlook: The best time of the day to take multivitamins.

So, when is the best time to take multivitamins — Morning or night?

Most experts lean toward morning — but the real answer is whenever your body absorbs best, and that depends on the vitamin.*

Morning

Best for most multis

They stimulate brain function and metabolism, and digestion slows during sleep — so late-night nutrients are likely absorbed less well.*

Night

For a few like vitamin E

Vitamin E has a neuroprotective effect and may help those who struggle to sleep — so it's best with dinner or before bed.*

Well, you may read different opinions from different resources across search engines and social media platforms. Some experts like Jeffrey Blumberg (a professor) and Neil Levin (a clinical nutritionist) agreed that multivitamins tend to perform best when taken in the morning as they stimulate brain function and metabolism, which can be too much for a relaxing evening. Blumberg also stated that digestion slows down during sleep, so taking nutrient supplements late at night is likely to reduce absorption.*1

Determining the best time to take multivitamins shouldn't be rocket science or even set in stone. It's pretty simple — it's when your body's absorption is at its maximum, plus it also depends on the type of vitamin.

Here's a breakdown of when specific vitamins should be taken:

When to take each kind*

Water-solubleHover / tap
B vitamins & vitamin C — best on an empty stomach, first thing in the morning.*
Fat-solubleHover / tap
A, D, E & K — take with a meal that contains some fat for maximum absorption.*
MineralsHover / tap
Calcium, iron & magnesium can upset an empty stomach — take them with food.*

Tap or hover a card to see when each type is best absorbed.*

Water-soluble vitamins

Vitamin C and the B's love an empty stomach — morning is their moment, and B6 can keep you sharp through the day.*

Woman taking her morning multivitamin drink at a sunlit kitchen counter
Water-soluble vitamins are best absorbed first thing in the morning, before breakfast.*

Dr. Perez Gallardo of Cleveland Clinic recommended taking water-soluble vitamins such as Vitamin C and B12 on an empty stomach. All B Vitamins, except folate, is vital in our body's energy production.* Vitamin B6, for instance, has anti-stress properties, which help to improve our mood and promote brain function to keep us productive and focused during the day.* Obviously, taking it at night is not ideal as it can interfere with sleep and cause vivid dreams.*

Fat-soluble vitamins

Vitamins like E carry antioxidant and neuroprotective perks — making dinner or bedtime their sweet spot.*

A study published by the National Library of Medicine tackled that REM sleep deprivation alters calcium ion concentration, membrane-bound ATPases, membrane fluidity, and gene expression.* These alterations are likely to induce changes in cellular physiology, including the spike in the generation of free radicals.* Now, how does it relate to taking vitamins?2

There are vitamins like Vitamin E that contain antioxidant properties and offer a lot of benefits to people who are struggling to sleep at night.* Vitamin E has a neuroprotective effect, so it is best taken with dinner or before bedtime.*

It's also worth mentioning that fat-soluble vitamins, including vitamin D, are best taken after eating foods that contain fat.* You won't actually need too much fat. Dr. Perez-Gallardo shared that even small amounts of whole or low-fat milk or yogurt can do the trick.

With food or without food?

Some multis ride along better with a meal; a few work best on a clean, empty stomach. Here's the simple split.*

Multivitamins are often taken in the morning, but there are specific vitamins that are best taken with food and others that are best taken on an empty stomach.

With food

Fat-soluble vitamins and a few minerals are gentler — and better absorbed — when they ride along with a meal.*

Healthy breakfast of avocado toast, eggs and tomatoes to help fat-soluble vitamins absorb
A little healthy fat at breakfast helps vitamins A, D, E and K absorb.*

Vitamins A, D, E, and K should be taken in conjunction with a meal for maximum absorption.* Vitamin D works best with the largest meal of the day.

Supplements that are not ideal to be taken on an empty stomach are calcium, iron, and magnesium, as they are likely to upset your stomach.* So, taking these vitamins with food will improve absorption and aid digestion.*

Without food

Water-soluble vitamins absorb best on an empty stomach — and your body simply flushes any extra.*

A glass of water beside fresh berries on a sunlit morning counter for water-soluble vitamins
A glass of water and an empty stomach is all your B's and C need.*

Water-soluble vitamins, especially B vitamins and vitamin C, are best absorbed in the body on an empty stomach.* So, taking them as soon as you wake up or before breakfast is ideal. Fun fact! The human body only takes what it needs from water-soluble vitamins, so the rest are just excreted through urine.

How about prenatal multivitamins?

Prenatals pack a lot in — pairing them with breakfast or lunch keeps nausea and reflux at bay.*

Now let's talk about the best time of the day to take prenatal vitamins!

While most nutritionists suggest that we can get the essential nutrients from the food we eat, not everyone is in a position to eat well, like pregnant moms who usually endure the annoying changes brought by morning sickness.

Pregnant woman eating breakfast as the best time to take a prenatal multivitamin
Taking a prenatal with breakfast or lunch helps prevent nausea and acid reflux.*

Prenatal multivitamins typically contain different types of vitamins and minerals, so it's quite tricky to determine whether to take them when we're full or when our tummy's empty. While there is prenatal multi like Root'd that is safe to be taken any time of the day, you may want to take it with your breakfast or lunch to prevent nausea and lower the chance of an upset stomach or acid reflux.

Root'd Prenatal MULTI is also infused with sugar-free electrolytes as our thoughtful consideration to help you replenish lost electrolytes due to morning sickness and to keep you and your baby healthy and hydrated.*

Who should take multivitamins?

Adults, vegans and vegetarians tend to gain the most — but a quick chat with your doctor beats guessing.*

Two groups who benefit most*

0
key nutrients harder to absorb as we age: B12 & vitamin D*
0
nutrients vegans & vegetarians often miss: omega-3s, iron, calcium, B12 & D*

Absorption of B12 and vitamin D decreases with age, and plant-based diets can run low on omega-3s, iron, calcium, B12 and D.*

Adults usually benefit the most from taking multivitamins. Absorption of essential vitamins such as vitamin B12 and vitamin D decreases as we age, so taking food supplements may help to address this issue.*3

Vegans and vegetarians should also take nutritional supplements and vitamins since they usually don't get enough omega-3s, iron, calcium, and vitamins B12 and D.*

When it comes to supplements and vitamins, everyone's body is different—which means that what works for your besties might not work for you. That's why it's always best to consult a doctor before taking any supplement or multivitamin. They can recommend the best option for your specific needs and health goals.

Want a multi that's easy on the stomach and works any time of day? Meet Root'd MULTI →

Root'd MULTI hydrating daily multivitamin drink mix

Pick your Root'd

★★★★★ 1,000+ 5-star reviews

Choose your supply

Learn more →

Use code for off + free shipping on your first order

🔒 100% Love Guarantee · 25 nutrients + electrolytes · 0g added sugar

FAQs

Best time to take multivitamins, answered

Experts tend to agree multivitamins perform best in the morning, since they stimulate brain function and metabolism, and digestion slows down during sleep, which can reduce absorption late at night.* The real answer is whenever your body's absorption is at its maximum, and that also depends on the type of vitamin.*

Fat-soluble vitamins A, D, E and K should be taken with a meal for maximum absorption, and vitamin D works best with the largest meal of the day.* Calcium, iron and magnesium are also best taken with food because they can upset an empty stomach.*

Water-soluble vitamins, especially the B vitamins and vitamin C, are best absorbed on an empty stomach, so taking them as soon as you wake up or before breakfast is ideal.* Your body only takes what it needs and excretes the rest through urine.

Root'd Prenatal is safe to take any time of day, but you may want to take it with breakfast or lunch to prevent nausea and lower the chance of an upset stomach or acid reflux.* It's also infused with sugar-free electrolytes to help replenish what's lost to morning sickness.*

Adults usually benefit most, since absorption of vitamins like B12 and vitamin D decreases as we age.* Vegans and vegetarians may also benefit, as they often don't get enough omega-3s, iron, calcium, and vitamins B12 and D.* Everyone's body is different, so it's always best to consult a doctor first.

References

  1. Tufts / Penn Medicine — experts on morning vs. night vitamin timing. Source
  2. National Library of Medicine (NIH/PMC) — REM sleep deprivation & cellular physiology. Source
  3. National Institute on Aging (NIH) — vitamins & minerals for older adults. Source

Leave a comment

This site is protected by hCaptcha and the hCaptcha Privacy Policy and Terms of Service apply.


Quick view
Root'd Her MULTI coral pouch — women's hydrating multivitamin drink mix with 25 nutrients and electrolytes, 30 count
Root'd Her MULTI women's hydrating multivitamin drink mix pouch with a mixed glass
Advanced Daily Nutrition - Formulated for Her
Get Hers
Quick view
Root'd His MULTI blue pouch — men's hydrating multivitamin drink mix with 24 nutrients and 9 superfoods, 30 count
Root'd His MULTI men's hydrating multivitamin drink mix pouch with a mixed glass
Advanced Daily Nutrition - Formulated for Men
Get His
Quick view
Root'd Prenatal MULTI purple pouch — hydrating prenatal vitamin drink mix with 25 nutrients and methylfolate, 30 count
Root'd Prenatal MULTI prenatal vitamin drink mixed in a glass beside the pouch on a kitchen counter
Essential Prenatal Nutrition + Electrolytes
Get Prenatal
Quick view
Essential Prenatal Nutrition + Electrolytes & DHA
Essential Prenatal Nutrition + Electrolytes & DHA
Essential Prenatal Nutrition + Electrolytes & DHA
Get Prenatal + DHA

View all

View all